Nice videos but i think you made a mistake here. You said Renin is secreted by the kidneys and is turned into Angiotensin I to Angiotensin II. This is incorrect. Angiotensinogen is converted by Renin to Angiotensin I and then Angiotensin Converting Enzyme (ACE) converts Angiotensin I to Angiotensin II.
You are absolutely correct… i think i was high when i said that lol. Anyways, renin secreted by JG cells of afferent arterioles in response to low blood pressure or low plasma sodium will convert angiotensinogen (a plasma protein secreted by liver) into ANG-I, which is converted to ANG-II by ACE (found in the endolthelia of blood vessels and lung capillaries). ANG-II will increase blood pressure, sodium, and stimulate thirst by acting on circumventricular organs of the brain such as SO :P
Hey dude your blog is great but this blog is for LAY and for undergraduate students… please read medical books and advanced physiology books to see the exact location of of cellular regulation & phsyiologic responses ( exact & correct)
Dr. Roxas
I am so grateful for your videos. They helped me get through my anatomy class and I’m still finding them helpful with physiology. I wish you had them for microbiology! Or maybe we just need two of you!
Hello there, thanks for the reply, i mean is that your film is really cool and great but i suggest you read physiology by bern and levy .. you will say more regarding to such info’s.
Bronchoconstriction: When H1 receptor binding of histamine mediates release of calcium that binds to troponin c of smooth muscle of the bronchi and causes muscle shortening ===> Bronchoconstriction thereby reducing air flow.
You can tell more about the products that you have already known. Try read something about cellular interactions..
Renin is released in the JG Cells with the following criteria:
a. Reduced Inter-arteriolar pressure in the afferent arteriole due to:
– Reduction of Blood Flow such as blood loss
- Reduced pressure mediated by vasoconstriction
- Epinepherine Activation
- Macula Densa activation with decreased Sodium Concentration in the Distal convoluted Tubule in the Na-chanells
If the Rennin is released in the JG cells this now converts your Prohormone ANGIOTENSINOGEN to ANGIOTENSIN 1 (liver/ hepatocyte) the To ANGIOTENSIN 2 (Endothelial cells of the alveoli via Angiotensin Converting Enzyme)
ANGIOTENSIN 2 binds to AT1 Receptor that elicits the following criteria:
a. Vasoconstriction ==> Inc. BP
b. Aldosterone Release in the zona glomerulosa ==> Dec U/O
c. Cardiac Remodelling ==> Enlarge heart
Hey bro great video, slow down a bit though, take it easy on the sympathomimetic amines, or at least lay off the coffee. I love your passion but sometimes you get lost in the moment.
Hey thank you very much for your great explanations.
But there is one logical mistake.
Previously you told us that if we excersise the sympathetic organs as Heart, Muscles and Skin receive more blood. Therefore the arteries dialate to be able to deliver more Oxygen in form of Hb to the organs.
But now you tell that during sympathetic activation there occurs a Vasoconstriction which means the arteries are constricted, and the skin gets pale. But how is that possible? Because during sympathetic activation the arteries of the skin will dialated to increase blood flow with the aim to release heat out of the body.
I would appreciate if you would help me in this case.
why do u think such??dats a wrong concept. dere’s no role of sympathetic sysytem in cooling da body…rather during shock, da symp system gets activated dat preferentially constricts da cutaneous vessels coz da alpha receptors dat constrict da vessels are more in vessels of skin. so da skin vessels get constricted n blood is bypassed to internal organs to save da patient….dats da same reason 4which we give adrenaline!!!
October 4th, 2008 - 08:43
good job…! May i get more videos in cardiovascular system.U make it easier for us to understand.
October 4th, 2008 - 08:46
which book do you use?you are great Hyperhighs..!
October 4th, 2008 - 15:09
Try Ole’s Physiology Lecture Notes… although this video was more from my own knowledge and from the material presented in my lecture.
November 1st, 2008 - 23:31
Nice videos but i think you made a mistake here. You said Renin is secreted by the kidneys and is turned into Angiotensin I to Angiotensin II. This is incorrect. Angiotensinogen is converted by Renin to Angiotensin I and then Angiotensin Converting Enzyme (ACE) converts Angiotensin I to Angiotensin II.
November 2nd, 2008 - 02:48
You are absolutely correct… i think i was high when i said that lol. Anyways, renin secreted by JG cells of afferent arterioles in response to low blood pressure or low plasma sodium will convert angiotensinogen (a plasma protein secreted by liver) into ANG-I, which is converted to ANG-II by ACE (found in the endolthelia of blood vessels and lung capillaries). ANG-II will increase blood pressure, sodium, and stimulate thirst by acting on circumventricular organs of the brain such as SO :P
November 2nd, 2008 - 19:50
Appreciate the effort put in to these videos, they have saved me a lot of time, many thanks.
November 19th, 2008 - 00:46
Great video! Thank you!
February 1st, 2009 - 04:03
Hey dude your blog is great but this blog is for LAY and for undergraduate students… please read medical books and advanced physiology books to see the exact location of of cellular regulation & phsyiologic responses ( exact & correct)
Dr. Roxas
April 7th, 2009 - 15:09
so nice thanks
May 24th, 2009 - 00:52
I am so grateful for your videos. They helped me get through my anatomy class and I’m still finding them helpful with physiology. I wish you had them for microbiology! Or maybe we just need two of you!
July 6th, 2009 - 15:56
i started taking Levodyn and it’s really great. i really felt great since i started taking it.
December 8th, 2009 - 04:34
What are you a doctor of…french? haha. of course this is for lay people, if you want advanced material read it yourself
December 8th, 2009 - 13:36
Hello there, thanks for the reply, i mean is that your film is really cool and great but i suggest you read physiology by bern and levy .. you will say more regarding to such info’s.
December 8th, 2009 - 13:36
Such example:
Bronchoconstriction: When H1 receptor binding of histamine mediates release of calcium that binds to troponin c of smooth muscle of the bronchi and causes muscle shortening ===> Bronchoconstriction thereby reducing air flow.
You can tell more about the products that you have already known. Try read something about cellular interactions..
But still continue this site its cool
December 8th, 2009 - 13:43
Renin is released in the JG Cells with the following criteria:
a. Reduced Inter-arteriolar pressure in the afferent arteriole due to:
– Reduction of Blood Flow such as blood loss
- Reduced pressure mediated by vasoconstriction
- Epinepherine Activation
- Macula Densa activation with decreased Sodium Concentration in the Distal convoluted Tubule in the Na-chanells
December 8th, 2009 - 13:46
If the Rennin is released in the JG cells this now converts your Prohormone ANGIOTENSINOGEN to ANGIOTENSIN 1 (liver/ hepatocyte) the To ANGIOTENSIN 2 (Endothelial cells of the alveoli via Angiotensin Converting Enzyme)
ANGIOTENSIN 2 binds to AT1 Receptor that elicits the following criteria:
a. Vasoconstriction ==> Inc. BP
b. Aldosterone Release in the zona glomerulosa ==> Dec U/O
c. Cardiac Remodelling ==> Enlarge heart
January 17th, 2010 - 05:09
Hey bro great video, slow down a bit though, take it easy on the sympathomimetic amines, or at least lay off the coffee. I love your passion but sometimes you get lost in the moment.
February 27th, 2010 - 14:44
I love your videos!! I like the way you explain things, you are so great at keeping it simple. THANK YOU!!!!
March 6th, 2010 - 10:22
Hey thank you very much for your great explanations.
But there is one logical mistake.
Previously you told us that if we excersise the sympathetic organs as Heart, Muscles and Skin receive more blood. Therefore the arteries dialate to be able to deliver more Oxygen in form of Hb to the organs.
March 6th, 2010 - 10:24
But now you tell that during sympathetic activation there occurs a Vasoconstriction which means the arteries are constricted, and the skin gets pale. But how is that possible? Because during sympathetic activation the arteries of the skin will dialated to increase blood flow with the aim to release heat out of the body.
I would appreciate if you would help me in this case.
March 8th, 2010 - 20:01
why do u think such??dats a wrong concept. dere’s no role of sympathetic sysytem in cooling da body…rather during shock, da symp system gets activated dat preferentially constricts da cutaneous vessels coz da alpha receptors dat constrict da vessels are more in vessels of skin. so da skin vessels get constricted n blood is bypassed to internal organs to save da patient….dats da same reason 4which we give adrenaline!!!
March 9th, 2010 - 03:11
I think you have to review the sympathetic nervous system in sweat glands. There is a correlation there. I think. :-)
March 25th, 2010 - 00:12
excellent, doctor.
May 23rd, 2010 - 04:07
These physiology videos are superb, you should definitely think of becoming a lecturer.
June 4th, 2010 - 15:43
can u plz tell me how sino-aortic mechanism help to regulate blood pressure??